Many people are informed of the importance of progesterone during in vitro fertilization, so they pay extra attention to the progesterone value during pregnancy testing. After doing a test tube, it's very confusing to see that the doctor doesn't look at progesterone but instead looks at HCG. Is progesterone not important anymore? Let the editor of 592 Baobao Net tell you why.

Because blood HCG has a significant impact on pregnancy during pregnancy. And progesterone is not very stable, so the significance of checking blood HCG during pregnancy is greater than that of checking progesterone. After making the wrist, on the 10th day, you can check the blood HCG to see if it has increased. You can also double check the blood HCG every other day to see if it has increased. If the increase is quite good, there are also cases of double increase, considering the possibility of successful transplantation. After 14 days of transplantation, blood tests can be performed or ultrasound can be performed one month later to check if the pregnancy is successful.

What is HCG?

Human chorionic gonadotropin (HCG) is a glycoprotein secreted by placental trophoblast cells, composed ofα Andβ Composition of dimeric glycoproteins. Glycoprotein hormone with a molecular weight of 36700,α The subunits and FSH (follicle stimulating hormone), LH (luteinizing hormone), and TSH (thyroid stimulating hormone) secreted by the pituitary gland are basically similar, so they can cross react with each other,β The structure of subunits varies. Mature women form embryos after the fertilized egg moves into the uterine cavity and is implanted. During the process of developing into a fetus, placental syncytiotrophoblast cells produce a large amount of HCG, which can be excreted into urine through the blood circulation of pregnant women. At 1-2 weeks of pregnancy, HCG levels in serum and urine can rapidly increase, reaching a peak at 8 weeks of pregnancy and decreasing to moderate levels at 4 months of pregnancy, until the end of pregnancy. The commonly used detection methods currently include latex aggregation inhibition test and hemagglutination inhibition test; Radioimmunoassay (RIA); Enzyme linked immunosorbent assay (ELISA); Monoclonal antibody colloidal gold test.

What is progesterone?

Progesterone is a family planning term released in 2019. A natural progesterone secreted by the corpus luteum of the ovary. Together with estrogen, it participates in the regulation of the hypothalamic pituitary ovarian axis; It can transform the proliferative endometrium into a secretory phase, providing favorable conditions for egg implantation and early embryo nutrition, and maintaining pregnancy; Under the joint action of estrogen, it promotes the development of breast lobules and glands; Promoting cervical mucus thickening is not conducive to sperm penetration; High doses can inhibit ovulation. It is used to treat menstrual disorders, premenstrual syndrome, luteal insufficiency, threatened miscarriage, and habitual miscarriage, and can also be used as a sustained-release progesterone drug for intrauterine devices.