What is the reason why gynecologists recommend a second price instead of a ninth price? In recent years, people's awareness of Human Papillomavirus (HPV) has gradually increased, and preventive measures have become an important health topic. HPV infection is one of the most common sexually transmitted infections in women, closely related to the occurrence of cervical cancer and other gynecological malignancies. At present, there are two types of HPV vaccines available on the market: bivalent and nine valent, but gynecologists are more inclined to recommend bivalent vaccines. So, why do gynecologists recommend using a bivalent HPV vaccine instead of a nine valent HPV vaccine? The following will provide a detailed explanation.

1、 Types and mechanisms of action of vaccines

1. Divalent vaccines:

The bivalent HPV vaccine simultaneously protects the immune system from HPV16 and 18 infections, which are the main causes of over 70% of cervical cancer. The viral like particles (VLP) in bivalent vaccines have a similar shell structure to HPV16 and 18, which prevent HPV infection by stimulating the immune system to produce antibodies.

2. Nine valent vaccine:

The nine valent HPV vaccine not only protects the immune system from HPV16 and 18 infections, but also prevents high-risk infections such as HPV31, 33, 45, 52, and 58. The nine valent vaccine also achieves the effect of preventing HPV infection by stimulating the immune system to produce antibodies.

2、 Reasons for gynecologist recommendations

1. Safety:

The bivalent vaccine has undergone large-scale clinical trials worldwide, and its safety has been fully verified. Although the nine valent vaccine has also undergone clinical trials, its side effects and long-term safety research data are relatively limited due to its inclusion of more HPV types. Gynecologists are more inclined to choose bivalent vaccines because their safety has been proven through long-term use.

2. Cost effectiveness:

Nine valent vaccines are more expensive than bivalent vaccines. Considering that the nine valent vaccine can prevent infection of a wider range of HPV types, it can indeed provide more comprehensive protection for certain specific populations (such as sexually active individuals, multiple sexual partners, etc.). But for most women, divalent vaccines are sufficient to prevent the occurrence of cervical cancer.

3. Time required:

The nine-valent vaccination takes a long time, a total of three months to complete. This may not be appropriate for situations that urgently require prevention, especially for women who have already had sexual activity. The bivalent vaccine only needs to be administered twice, with a shorter interval, making it more convenient and efficient.

4. Prevention and control effects of cervical cancer:

According to statistical data, HPV16 and HPV18 are the main causes of cervical cancer, accounting for more than 70% of the incidence rate of cervical cancer. In addition to protecting against HPV16 and 18 infection, the nine valent vaccine can also prevent other high-risk HPV types of infection. However, according to research, the infection rates of HPV16 and 18 types are relatively high in China, while the infection rates of other high-risk types are relatively low. Therefore, bivalent vaccines are sufficient to meet the prevention and control needs of cervical cancer in China.

What is the reason why gynecologists recommend a second price instead of a ninth price? The reasons why gynecologists recommend using a bivalent HPV vaccine instead of a nine valent HPV vaccine can be summarized as safety, cost-effectiveness, required time, and effectiveness in cervical cancer prevention and control. Although the nine valent vaccine can prevent multiple types of HPV infection, for most women, the bivalent vaccine is sufficient to provide effective cervical cancer prevention. In addition, gynecologists will also evaluate and recommend suitable vaccine types based on the specific situation of women.