Nowadays, the fertility rate in society is decreasing, and many families who marry and have children late have encountered some problems of infertility. Most of these problems are caused by acquired reproductive system infections or unhealthy lifestyles, but there are also some people whose reproductive problems are not caused by acquired factors, but by congenital factors. One of the more common types is the y-chromosome microdeletion. So, if this congenital chromosomal disease is diagnosed, can it still have fertility? Can Y-chromosome microdeletions be treated?

1、 Etiology of y chromosome microdeletions

Male Y chromosome deletion can lead to oligospermia and dystopia, which is a genetic problem. The current medical level of this disease cannot be cured, and the probability of normal pregnancy is very low. So it is recommended to choose to go to a reproductive center for relevant examinations, and then assist reproduction through in vitro fertilization. It is worth reminding that this chromosomal abnormality may be passed on to the next generation. Suggest going to the reproductive medicine department of a regular hospital to check for semen standards. If the quality is not good, try again. If it is not good, you can follow the doctor's advice to use relevant drugs and undergo regular examinations. But it cannot conceive naturally, and assisted reproduction can be used. Y chromosome deletion is not an important factor leading to male infertility.

2、 Can Y chromosome microdeletions be fertile?

Normal childbirth is usually not possible. Y chromosome deletion can lead to male infertility. It may be that there are special factors on the male sex chromosome that affect the formation of sperm in the male testicles, as well as the development and vitality of sperm, resulting in insufficient sperm vitality. Some minor deletions on the outer chromosome can cause a wife to conceive, but during pregnancy, abnormal embryonic development can easily lead to miscarriage. Patients with Y-chromosome microdeletions cannot conceive normally on their own, as Y-chromosome microdeletions are associated with azoospermia and oligospermia, and cannot be improved through medication. It is necessary to seek medical attention in a timely manner and communicate with the doctor to decide on a treatment plan. Although patients with Y-chromosome microdeletions cannot conceive normally, they should not give up hope. Modern assisted reproductive technology and development are both very good. Couples with Y chromosome microdeletions can try in vitro fertilization to assist in pregnancy.

3、 Treatment of y chromosome microdeletions

The treatment of Y chromosome microdeletions is a genetic deletion that determines spermatogenesis at the long arm end of the Y chromosome, including deletions in the A, B, C, and D regions. The testicles with missing areas A and B do not undergo spermatogenesis, so it is recommended to donate or adopt them. Due to the possible presence of sperm in the testes of patients with C-zone deficiency, some patients can find sperm through fiber collection and undergo in vitro fertilization to conceive their own children. The deletion of the C region of the Y chromosome can be transmitted to the next generation of boys through in vitro fertilization. It is recommended to use genetic counseling and third-generation IVF assisted pregnancy. The meaning of area D is unclear.

Y chromosome microdeletion is a difficult disease to solve, and if one is unlucky enough to miss a key gene, it is almost impossible to conceive. Even if it is possible to have children, it is not possible to have boys to avoid more severe chromosomal deletions and deformities. It is recommended to use the third generation IVF method for certain genetic screening.