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Can men be cured of azoospermia? Can we make a test tube?

2023-08-19 本站作者 【 字体:

As the name suggests, "azoospermia" refers to the absence of sperm in male semen, which is medically referred to as "no sperm found for three consecutive times", which is called azoospermia. There are two main types of azoospermia: obstructive and non obstructive. As the name suggests, obstructive azoospermia manifests as normal testicular spermatogenesis, but the vas deferens cannot be expelled due to inflammation, developmental abnormalities, and other blockages. When there is no obstructive azoospermia, the patient's vas deferens are unobstructed, but the testicles cannot produce sperm normally due to various reasons. So can male azoospermia be cured? Can we make a test tube?

Can men be cured of azoospermia? Can we make a test tube?(图1)

Generally, azoospermia can be treated through acquired factors. For example, infectious factors, exogenous factors, iatrogenic factors, environmental factors, drug effects, and local high temperatures can all lead to azoospermia. When being a second-generation IVF, as long as there are sperm, it is possible to conceive.

1. Obstruction of the vas deferens.

Obstructive insemination is the primary cause of azoospermia. Partial obstruction of semen through the testes, epididymal ducts, vas deferens, ejaculatory ducts, and urethra can hinder the discharge of sperm, resulting in obstructive azoospermia. Obstructive azoospermia requires surgery to clear the obstructed area, and after treatment, fertility can be restored

2. Congenital abnormalities of the testicles.

If there is no congenital testicle, underdeveloped testicles, or underdeveloped testicles, it can all lead to sperm production disorders, among which cryptorchidism is a common condition. After treatment, fertility may be restored or second-generation IVF may be required.

3. Testicular infection.

Bilateral orchitis includes viral mumps accompanied by bilateral orchitis (especially pre pubertal infections), which can easily lead to azoospermia. Treating inflammation can restore fertility.

4. Genital damage.

External factors may cause testicular torsion, injury, spermatic cord torsion, etc., as well as decreased testicular spermatogenic function due to trauma caused by scrotal, inguinal surgery, prostate surgery, etc. This situation is generally irreversible, but it is possible to choose to be a second-generation IVF and choose to use sperm for second-generation IVF.

5. Radiation, high temperature, and drug damage.

Long term exposure to radiation or high temperature environment; Long term exposure to chemical substances such as arsenic, aluminum, benzene, and amines; Long term use of chemical drugs can damage testicular spermatogenic cells, affect testicular spermatogenic function, and lead to azoospermia. It is difficult to recover from azoospermia caused by this reason, and it is recommended to do in vitro fertilization to increase the probability of fertilization.

6. Varicocele.

This disease can seriously affect the blood supply to the testes, affect their endocrine and metabolic functions, and ultimately lead to spermatogenic disorders.

7. Endocrine disorders.

Common diseases such as pituitary hyperfunction or hypofunction, pituitary tumors, adrenal hyperfunction or low levels, hyperthyroidism, severe systemic diseases, malnutrition, etc., may all affect sperm production.

Can men be cured of azoospermia? Can we make a test tube?(图2)

Congenital azoospermia cannot be cured, and without sperm, IVF fertilization cannot be performed.

1. Pretesticular infertility.

The male testicles themselves are normal, but the secondary cause is due to endocrine disorders in the hypothalamus and/or pituitary gland, leading to testicular underdevelopment or infertility.

2. Testicular infertility.

Due to various reasons, the male testicles themselves have lost the ability to produce sperm.

3. Posttesticular azoospermia.

Due to obstruction or congenital absence of the vas deferens in males, although a large amount of sperm is produced in the testicles, it cannot be expelled from the body, so there is no sperm in the semen.

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