Down syndrome, also known as "trisomy 21 syndrome". It is a chromosomal defect disease, also known as "congenital foolishness". It is the first child with mixed mental retardation syndrome. Chromosome 21 has changed from 2 normal to 3, making it one of the highest birth rate defects in China. How to prevent Down syndrome has become the primary task in vitro.

Therefore, China has been vigorously promoting prenatal screening for Down syndrome, abbreviated as Tang screening. The purpose is to determine the risk factors for congenital stupidity and neural tube defects in fetuses by detecting the concentrations of alpha fetoprotein, chorionic gonadotropin, and free estriol in maternal blood and serum, combined with the age, weight, and gestational age of the pregnant woman. Among them, 60% of children will miscarry in the fetus, and those who survive will also have significant intellectual disabilities and special facial features. And the offspring of infertility patients who choose to undergo in vitro fertilization are the most susceptible to genetic diseases, so the problem arises. How to prevent Down syndrome by doing in vitro fertilization?

The editor of 592 Baobao.com suggests choosing to become a third generation in vitro baby. The third generation in vitro baby technology can effectively avoid the invasion of up to 125 genetic diseases such as Down syndrome, and maximize the protection of the basic health of the fetus. There are several main methods for prenatal prevention: prenatal examination mainly focuses on the reproductive system and genetic factors, as healthy babies must be the combination of high-quality and healthy sperm and eggs, so both spouses must undergo prenatal examination. Through pre pregnancy examination, not only can some abnormal situations and diseases be detected, but also the transmission of genetic diseases can be prevented.

The older a woman is pregnant, the higher the risk of developing Down syndrome in the fetus. The risk of recurrence of standard Down syndrome is 1%, and parents of children with translocation should undergo karyotype analysis to find balanced translocation carriers. If the mother has D/G translocation, the risk rate for each child is 10%. The third-generation IVF PGD/PGS technology is the main laboratory examination technique for Down syndrome, which comprehensively solves the problem of chromosome translocation carriers and recurrent miscarriage patients by detecting chromosomal diseases across the entire genome.

Tang's high-risk population:

1. During pregnancy, the pregnant woman has a history of virus infections such as influenza and rubella; The five teratogenic tests can be used to diagnose whether pregnant women are infected with the aforementioned virus. The five teratogenic tests are TORCH tests, which include detection of Toxoplasma gondii, rubella virus, cytomegalovirus, and herpes simplex virus. The cost of TORCH testing is about 100 yuan. The TORCH test can be done within 3 months of pregnancy.

2. During pregnancy, chromosomal abnormalities in the couple; Pregnant women aged 34 and above undergo amniocentesis to check for chromosomal abnormalities in their fetuses;

For pregnant women under the age of 34, blood screening is performed to screen for chromosomal abnormalities in high-risk groups. Examination time: Pregnant women's blood screening and amniocentesis should be performed 15 to 20 weeks after mid pregnancy.

Pregnant women who have been pregnant with a Down baby are 10 times more likely to have a Down baby again than normal people.

4. The woman has taken teratogenic drugs such as tetracycline before and after pregnancy;

5. Pregnant women with a history of habitual miscarriage, premature birth, or stillbirth.