Chromosomal disease is a disease that many ordinary people fear like a tiger. Although it may sound terrifying, there are actually some chromosomal diseases that are not very serious, and patients are not much different from ordinary people. But there are many types of chromosomal abnormalities that can lead to infertility. There is a type of chromosomal abnormality called hyperandrogenicity syndrome, in which the patient's chromosomes are different from the XY of normal men, but instead become the three XYY chromosomes. So do patients with this type of hyperandrogenicity syndrome have fertility? Is this type of hyperandrogenicity syndrome treatable?

1、 Etiology of hyperandrogenicity syndrome

Hyperandrogen syndrome, also known as XYY chromosome syndrome, refers to the excess Y chromosome in a boy's body at birth. Children with XYY chromosome syndrome are usually tall and have language disorders. The causes of most birth defects are not yet clear, and it has been proven that some factors can increase the risk of birth defects, including nutritional deficiencies, radiation, certain medications, alcohol consumption, maternal infections and diseases, trauma, and genetic diseases. Any factor that can cause or increase the risk of birth defects is called a teratogenic factor, and radiation, certain drugs, and toxins are all teratogenic factors. When a fetus is exposed to teratogenic factors during a certain developmental period, different teratogenic factors can lead to the same birth defect. On the other hand, exposure to the same teratogenic factors during different pregnancies can lead to different birth defects. In short, pregnant women should consult a doctor before taking medication. Pregnant women should quit smoking and alcohol, and avoid taking X-rays unless absolutely necessary. If it is necessary to undergo an X-ray examination, a pregnant woman should inform a radiologist or technician that she is pregnant, in order to protect the fetus as much as possible.

2、 Does hyperandrogenicity syndrome have fertility?

Whether a child with high androgen syndrome can be born should be decided jointly by both spouses. Hyperandrogen syndrome is a disease with abnormal sex chromosomes. There are more chromosomes than normal people. The more chromosomes, the lower the intelligence of the baby. After birth, there may be varying degrees of menstrual disorders, decreased fertility, or infertility. There are many adverse manifestations, some patients can lead to infertility, while others can be cured through routine treatment. If the manifestations of congenital testicular agenesis are similar to those of congenital testicular agenesis, such as small testicles, children without pubic hair or sparse pubic hair, it is necessary to pay attention to this aspect. Testicular underdevelopment is accompanied by spermatogenesis, decreased fertility, hypospadias, etc., But most men can have children.

3、 Can hyperandrogenicity syndrome be treated?

Hyperandrogen syndrome, also known as XYY chromosome syndrome, is a type of patient with chromosome 47XYY, first discovered in 1961. In their sex chromatin, X chromatin is negative and Y chromatin is double positive. The chromosome karyotype is 47, XYY, and the extra Y chromosome is due to the non separation of chromosomes during meiosis in the father's reproductive cells. This is a congenital disease. If such chromosomal abnormalities can be detected during childhood, early psychological regulation and supplementary endocrine therapy should be carried out, and special education for individuals with low intelligence should be strengthened to reduce the occurrence of intellectual disability. To avoid misdiagnosis, mentally ill patients should undergo a sex chromosome examination. In terms of treatment, appropriate comprehensive treatment methods should be adopted, such as changing the environment, reducing social isolation, psychological counseling, and small amounts of medication, rather than long-term hospitalization and medication.

Hyperandrogenic syndrome is one of the most common and least harmful chromosomal inherited diseases, and it usually does not cause significant harm to patients. Moreover, there are no issues with fertility and there will be no infertility. However, the condition of hyperandrogenicity can still cause some endocrine problems, which require adjustment under the guidance of a doctor and will not have a significant impact on daily life!